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Invitrogen™ Synuclein alpha/beta Recombinant Rabbit Monoclonal Antibody (ST05-21)
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Catalog No. PIMA532176
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PIMA532176 100 μL
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Catalog No. PIMA532176 Supplier Invitrogen™ Supplier No. MA532176
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
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Specifications

Antigen Synuclein alpha/beta
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Recombinant Monoclonal
Clone ST05-21
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene Snca
Gene Accession No. O55042, P37377, P37840, Q16143, Q63754, Q91ZZ3
Gene Alias AI838531; alphaSYN; alpha-synuclein; betaSYN; Beta-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Phosphoneuroprotein 14; PNP 14; SNCA; Sncb; Syn; synuclein alpha; synuclein alpha-140; synuclein beta; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); synuclein, beta
Gene Symbols Snca, SNCB
Host Species Rabbit
Immunogen Synthetic peptide within Human alpha+beta Synuclein aa 2-50.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 104069, 113893, 20617, 29219, 6620, 6622
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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