Invitrogen™ Synuclein alpha/beta Recombinant Rabbit Monoclonal Antibody (ST05-21)

Catalog No.	Quantity
PIMA532176	100 μL

Catalog No. PIMA532176

Supplier: Invitrogen™ MA532176

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

Specifications

• Antigen: Synuclein alpha/beta
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: ST05-21
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: Snca
• Gene Accession No.: O55042, P37377, P37840, Q16143, Q63754, Q91ZZ3
• Gene Alias: AI838531; alphaSYN; alpha-synuclein; betaSYN; Beta-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Phosphoneuroprotein 14; PNP 14; SNCA; Sncb; Syn; synuclein alpha; synuclein alpha-140; synuclein beta; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); synuclein, beta
• Gene Symbols: Snca, SNCB
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human alpha+beta Synuclein aa 2-50.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 104069, 113893, 20617, 29219, 6620, 6622
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG