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Invitrogen™ SYPL2 Polyclonal Antibody
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Catalog No. PIPA5139947
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100 μL
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PIPA5139947 100 μL
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Catalog No. PIPA5139947 Supplier Invitrogen™ Supplier No. PA5139947
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FKETPWHGQG QGQDQDQDQD QGQGPSQESA AEQGAVE Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 78%.

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SYPL2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SYPL2
Gene Accession No. Q5VXT5
Gene Alias AI552439; MG29; mitsugumin 29; mitsugumin29; mitsugumin-29; synaptophysin like 2; synaptophysin-like 2; synaptophysin-like protein 2; Sypl2; UNQ6348
Gene Symbols SYPL2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SYPL2. Recombinant protein control fragment (Product #RP-109577).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 284612
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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