Invitrogen™ SYPL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5139947

Catalog No. PIPA5139947

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FKETPWHGQG QGQDQDQDQD QGQGPSQESA AEQGAVE.

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.

Specifications

• Antigen: SYPL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYPL2
• Gene Alias: AI552439; MG29; mitsugumin 29; mitsugumin29; mitsugumin-29; synaptophysin like 2; synaptophysin-like 2; synaptophysin-like protein 2; Sypl2; UNQ6348
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 284612
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5VXT5
• Gene Symbols: SYPL2
• Immunogen: Recombinant protein corresponding to Human SYPL2. Recombinant protein control fragment (Product #RP-109577).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG