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Tocris Bioscience™ SZL P1-41
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Catalog No. 507650 Shop All R&D Systems Products
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50-765-0 50mg
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Catalog No. 50-765-0 Supplier Tocris Bioscience™ Supplier No. 5076/50
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Description

Selective Skp2 inhibitor; suppresses E3 ligase activity

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Specifications

Quantity 50 mg
Product Type SZL P1-41
Purity >98%
Molecular Weight (g/mol) 420.52
Inhibitors SZL P1-41

For Research Use Only

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