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  6. Invitrogen™ T-bet Monoclonal Antibody (eBio4B10 (4B10)), Alexa Fluor™ 660, eBioscience™, Invitrogen™ 

Invitrogen™ T-bet Monoclonal Antibody (eBio4B10 (4B10)), Alexa Fluor™ 660, eBioscience™, Invitrogen™

Catalog No. 606582580
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60-658-2580 25 μg
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Catalog No. 60-658-2580 Supplier Invitrogen™ Supplier No. 606582580
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Description

Mouse Monoclonal Antibody

The eBio4B10 (4B10) MAb reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
TRUSTED_SUSTAINABILITY

Specifications

Antigen T-bet
Applications Flow Cytometry
Classification Monoclonal
Clone eBio4B10 (4B10)
Concentration 0.2 mg/mL
Conjugate Alexa Fluor 660
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Tbx21
Gene Accession No. Q9JKD8, Q9UL17
Gene Alias HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21
Gene Symbols Tbx21
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30009, 57765, 694044
Target Species Human, Mouse, Rhesus Macaque
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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