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Invitrogen™ T-bet Polyclonal Antibody
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Catalog No. PIPA528881
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100 μL
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Catalog No. Quantity
PIPA528881 100 μL
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Catalog No. PIPA528881 Supplier Invitrogen™ Supplier No. PA528881
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, IMR32, U87-MG. Predicted reactivity: Mouse (96%), Rat (97%), Pig (97%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
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Specifications

Antigen T-bet
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Tbx21
Gene Accession No. Q9UL17
Gene Alias HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21
Gene Symbols Tbx21
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TBX21. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30009
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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