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  6. Invitrogen™ T-bet Recombinant Rabbit Monoclonal Antibody (BLR110H)

Invitrogen™ T-bet Recombinant Rabbit Monoclonal Antibody (BLR110H)

Catalog No. PIMA544412
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100 μL
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PIMA544412 10 μL
PIMA544411 100 μL
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Catalog No. PIMA544412 Supplier Invitrogen™ Supplier No. MA544412
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
TRUSTED_SUSTAINABILITY

Specifications

Antigen T-bet
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR110H
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 7.8-8.6
Gene Tbx21
Gene Accession No. Q9UL17
Gene Alias HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21
Gene Symbols Tbx21
Host Species Rabbit
Immunogen Peptide representing a region between residue 485 and the C-terminus (residue 535) of Human T-box transcription factor TBX21.
Purification Method purified
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30009
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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