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T2R38 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988692
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50-198-8692 100 μL
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Catalog No. 50-198-8692 Supplier Bioss Supplier No. BS8650R
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Description

Rabbit Polyclonal Antibody

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting); also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

Specifications

Antigen T2R38
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene TAS2R38
Gene Accession No. P59533
Gene Alias mT2R31; PTC; PTC bitter taste receptor; RGD:1560649}; T2R138; T2R26; T2r31; T2r38; T2r38 {ECO:0000312; T2R61; Tas2r138; Tas2r26; TAS2R38; taste 2 receptor member 38; Taste receptor type 2 member 26; Taste receptor type 2 member 38; Taste receptor type 2 member 61; taste receptor, type 2, member 138; taste receptor, type 2, member 38
Gene Symbols TAS2R38
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human T2R38/TAS2R38.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5726
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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