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Tocris Bioscience™ T4
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Catalog No. 705410
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70-541-0 10 mg
70-545-0 50 mg
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Description

Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3

T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively). T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling. T4 exhibits no inhibitory activity against a panel of 414 kinases. T4 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC50 = 0.07 μM).

Specifications

Chemical Name or Material 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2 H)-yl)methyl)]quinazolin-4(3 H)-one
CAS 785708-33-0
Quantity 10 mg
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C22H23N3O3
Purity 0.98
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