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Invitrogen™ T4S20 Polyclonal Antibody
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Catalog No. PIPA566779
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100 μL
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PIPA566779 100 μL
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Catalog No. PIPA566779 Supplier Invitrogen™ Supplier No. PA566779
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IHPESFNLQWF FNDSCAPPTG FNKPTSNDTM ASGWRASSFH FDSEENKHRL IHFSV Highest antigen sequence identity to the following orthologs - mouse 52%, rat 52%.

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
TRUSTED_SUSTAINABILITY

Specifications

Antigen T4S20
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TM4SF20
Gene Accession No. Q53R12
Gene Alias PRO994; SLI5; TCCE518; TM4SF20; transmembrane 4 L six family member 20; transmembrane 4 L6 family member 20; UNQ518/PRO994
Gene Symbols TM4SF20
Host Species Rabbit
Immunogen Recombinant protein fragment of Human TM4SF20 (Product #RP-104287)
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79853
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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