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Invitrogen™ T4S20 Polyclonal Antibody
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Catalog No. PIPA569644
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PIPA569644 100 μL
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Catalog No. PIPA569644 Supplier Invitrogen™ Supplier No. PA569644
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Dog: 77%; Human: 100%; Rabbit: 83%; Rat: 83%.

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
TRUSTED_SUSTAINABILITY

Specifications

Antigen T4S20
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene TM4SF20
Gene Accession No. Q53R12
Gene Alias PRO994; SLI5; TCCE518; TM4SF20; transmembrane 4 L six family member 20; transmembrane 4 L6 family member 20; UNQ518/PRO994
Gene Symbols TM4SF20
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human T4S20.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79853
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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