Invitrogen™ T4S20 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA569644

Catalog No. PIPA569644

Description

This target displays homology in the following species: Dog: 77%; Human: 100%; Rabbit: 83%; Rat: 83%.

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).

Specifications

• Antigen: T4S20
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TM4SF20
• Gene Alias: PRO994; SLI5; TCCE518; TM4SF20; transmembrane 4 L six family member 20; transmembrane 4 L6 family member 20; UNQ518/PRO994
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79853
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q53R12
• Gene Symbols: TM4SF20
• Immunogen: synthetic peptide directed towards the middle region of human T4S20.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG