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Invitrogen™ TAB1 Monoclonal Antibody (2G4)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA532953
Description
Purity is > 95% by SDS-PAGE.
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
Specifications
TAB1 | |
Monoclonal | |
1 mg/mL | |
TBS with 1% BSA, 50% glycerol and 0.03% ProClin 300; pH 7.4 | |
Q15750, Q8CF89 | |
TAB1 | |
Synthetic peptide, corresponding to the N-terminus of Human TAB1. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Western Blot | |
2G4 | |
Unconjugated | |
TAB1 | |
2310012M03Rik; 3'-Tab1; b2b449Clo; beta activated kinase-1 binding protein-1; MAP3K7IP1; MGC57664; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; RP3-407F17.2; TAB1; TAB1beta; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1 | |
Mouse | |
Antigen Affinity Chromatography | |
RUO | |
10454, 315139, 66513 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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