Invitrogen™ TAB182 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142021

Catalog No. PIPA5142021

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000. Preliminary analysis showed no signal in Western Blot.

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Specifications

• Antigen: TAB182
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNKS1BP1
• Gene Alias: 182 kDa tankyrase-1-binding protein; KIAA1741; TAB182; tankyrase 1 binding protein 1; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a; TNKS1BP1
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 85456
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9C0C2
• Gene Symbols: TNKS1BP1
• Immunogen: Peptide with sequence KVSTLRESSAMAS-C (aa 2-14).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG