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TAB182 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501560392
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Catalog No. Quantity
50-156-0392 100 μL
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Catalog No. 50-156-0392 Supplier Bethyl Laboratories, Inc Supplier No. A301438A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Specifications

Antigen TAB182
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene TNKS1BP1
Gene Accession No. Q9C0C2
Gene Alias TAB182, 182 kDa tankyrase-1-binding protein, tankyrase 1-binding protein of 182 kDa
Gene Symbols TNKS1BP1
Host Species Rabbit
Immunogen Between 350 and 400
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 85456
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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