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Invitrogen™ TAB2 Polyclonal Antibody
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Catalog No. PIPA534365
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100 μg
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Catalog No. Quantity
PIPA534365 100 μg
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Catalog No. PIPA534365 Supplier Invitrogen™ Supplier No. PA534365
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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue. PA5-34365 can be used with blocking peptide PEP-1408.

TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAB2
Applications Immunohistochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Tab2
Gene Accession No. Q9NYJ8
Gene Alias 1110030N06Rik; A530078N03Rik; CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; mKIAA0733; OTTHUMP00000017388; Tab2; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Gene Symbols Tab2
Host Species Rabbit
Immunogen A 14 amino acid synthetic peptide near the carboxy terminus of human TAB2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23118
Target Species Human
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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