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Invitrogen™ Tab2 Polyclonal Antibody
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Catalog No. PIPA597273
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PIPA597273 100 μL
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Catalog No. PIPA597273 Supplier Invitrogen™ Supplier No. PA597273
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TLAHVDRISE TRKLSMGSDD AAYTQALLVH QKARMERLQR ELEIQKKKLD KLKSEVNEME NNLTRRRLKR SNSISQIPSL EEMQQLRSCN RQLQIDIDCL TKEIDLFQAR G Positive Samples: HeLa, HepG2, MCF7, HT-1080, Mouse liver; Cellular Location: Cytoplasm, Membrane, Peripheral membrane protein, cytosol.

TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tab2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene Tab2
Gene Accession No. Q5U303, Q99K90, Q9NYJ8
Gene Alias 1110030N06Rik; A530078N03Rik; CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; mKIAA0733; OTTHUMP00000017388; Tab2; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Gene Symbols Tab2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 510-620 of human TAB2 (NP_0559081).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23118, 308267, 68652
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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