Invitrogen™ TAB3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114782

Catalog No. PIPA5114782

Description

Antibody detects endogenous levels of total TAB3.

TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

Specifications

• Antigen: TAB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tab3
• Gene Alias: 4921526G09Rik; Kiaa4135; MAP3K7IP3; mitogen activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7-interacting protein 3; mKIAA4135; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; Tab3; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 257397, 66724
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q571K4, Q8N5C8
• Gene Symbols: Tab3
• Immunogen: A synthesized peptide derived from human TAB3(Accession Q8N5C8), corresponding to amino acid residues Q251-P301.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov