Invitrogen™ TAB3 Polyclonal Antibody

Catalog No.	Quantity
PIPA5116885	100 μL

Catalog No. PIPA5116885 Supplier Invitrogen™ Supplier No. PA5116885

Description

Rabbit Polyclonal Antibody

Positive Samples: HepG2, Mouse spleen, Mouse heart, Rat testis Immunogen sequence: QPSPRNQHSL YTATTPPSSS PSRGISSQPK PPFSVNPVYI TYTQPTGPSC TPSPSPRVIP NPTTVFKITV GRATTENLLN LVDQEERSAA P.

TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

Specifications

• Antigen: TAB3
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.55 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Tab3
• Gene Accession No.: Q571K4, Q8N5C8
• Gene Alias: 4921526G09Rik; Kiaa4135; MAP3K7IP3; mitogen activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7-interacting protein 3; mKIAA4135; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; Tab3; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
• Gene Symbols: Tab3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 390-480 of human TAB3 (NP_6900003).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 257397, 317546, 66724
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG