Invitrogen™ TACC3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552207

Catalog No. PIPA552207

Description

Immunogen sequence: MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA KAMKVTFQTP LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK EN Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 75%.

TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.

Specifications

• Antigen: TACC3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TACC3
• Gene Alias: Aint; Arnt interacting protein; ARNT-interacting protein; C86661; ERIC1; ERIC-1; Tacc3; transforming acidic coiled coil 3; transforming acidic coiled-coil containing protein 3; transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10460
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6A5
• Gene Symbols: TACC3
• Immunogen: Recombinant protein corresponding to Human TACC3. Recombinant protein control fragment (Product #RP-88723).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG