Invitrogen™ TACR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596611

Catalog No. PIPA596611

Description

Immunogen sequence: YCCLNKRFRA GFKRAFRWCP FIKVSSYDEL ELKTTRFHPN RQSSMYTVTR MESMTVVFDP NDADTTRSSR KKRATPRDPS FNGCSRRNSK SASATSSFIS SPYTSVDEYS; Positive Samples: HL-60, Human placenta; Cellular Location: Cell membrane, Multi-pass membrane protein.

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

Specifications

• Antigen: TACR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tacr3
• Gene Alias: G protein-coupled receptor; HH11; neurokinin 3 receptor; Neurokinin B; neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); neuromedin-K receptor; Nk3 receptor; NK-3 receptor; NK3R; NK-3R; NK3R TAC3R; Nkr; Nmkr; Nmk-r; TAC3R; TAC3RL; tachikin receptor 3; tachykinin receptor 3; Tacr3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21338, 24808, 6870
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P16177, P29371, P47937
• Gene Symbols: Tacr3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_0010501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG