MilliporeSigma™ TAF10/TAFII30, Mouse, Unlabeled, Clone: 23TA-1H8,

Catalog No.	Quantity	Conjugate
MABE1078MI	100 μL	Unconjugated

Catalog No. MABE1078MI Supplier MilliporeSigma™ Supplier No. MABE1078

Description

Mouse Monoclonal Antibody

Transcription initiation factor TFIID subunit 10 (UniProt Q12962; also known as STAF28, TAF(II)30, TAFII-30, TAFII30, Transcription initiation factor TFIID 30kDa subunit) is encoded by the TAF10 (also known as TAF2A, TAF2H, TAFII30) gene (Gene ID 6881) in human.Transcription initiation factor TFIID subunit 10 (UniProt Q12962; also known as STAF28, TAF(II)30, TAFII-30, TAFII30, Transcription initiation factor TFIID 30kDa subunit) is encoded by the TAF10 (also known as TAF2A, TAF2H, TAFII30) gene (Gene ID 6881) in human. TAF10 (TAFII30) is a subunit of both the general transcription factor (GTF) TFIID and the coactivator SAGA (Spt-Ada-Gcn5-acetyltransferase) histone acetyltransferase (HAT) complexes involved in the initiation of RNA polymerase II (Pol II) transcription in eukaryotes. TFIID complex is composed of the TATA-binding protein (TBP) and thirteen TBP-associated factors (TAFs) that allow its recognition of not only TATA box-containing, but also TATA-less promoters for site-specific assembly of preinitiation complex (PIC). TAF10-knockout studies in mice indicate that TAF10 plays an important role during embryonic development and homeostasis in a tissue-dependent manner. TAF10 ablation is reported to result in severe anemia and lethality at embryonic stage E13.5 due to impaired erythropoiesis. In addition, TAF10 is shown to not only interact with the transcription factor GATA1, but also regulate its transcription as evidenced by its occupancy at GATA1 genomic locus in human fetal erythroid cells.

Specifications

• Antigen: TAF10/TAFII30
• Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 23TA-1H8
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Mouse monoclonal IgG1κ ascites with 0.05% Sodium Azide.
• Gene: TAF10, TAF2A, TAF2H, TAFII30
• Gene Accession No.: Q12962
• Host Species: Mouse
• Immunogen: Ovalbumin-conjugated linear peptide corresponding to the N-terminal sequence of human TAF10/TAFII30.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Epigenetics & Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_006275
• Test Specificity: Clone 23TA-1H8 (a.k.a. 1H8, 23TA 1H8, 23TA1H8) recognizes an N-terminal epitope present in human (UniProt Q12962), but not mouse (UniProt Q8K0H5), TAF10 (TAFII30) sequence.
• Target Species: Human
• Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
• Form: Ascites
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.