Invitrogen™ TAF6 Monoclonal Antibody (25TA-2G7)

Catalog No.	Quantity
PIMA3077	50 μL

Catalog No. PIMA3077 Supplier Invitrogen™ Supplier No. MA3077

Description

Mouse Monoclonal Antibody

MA3-077 detects TATA Binding protein (TBP) Associated factor 6 in human and mouse samples. MA3-077 has been successfully used in a Western blot application. The MA3-077 immunogen is a synthetic peptide coupled to ovalalbumin, from aa 39 to aa 56.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.

Specifications

• Antigen: TAF6
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 25TA-2G7
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Ascites with 0.05% sodium azide
• Gene: TAF6
• Gene Accession No.: P49848, Q62311
• Gene Alias: 80kDa; AW549759; DKFZp781E21155; MGC:8964; p80; RNA polymerase II TBP-associated factor subunit E; RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAF(II)70; TAF(II)80; TAF2E; Taf6; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kDa; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFII70; TAFII-70; TAFII80; TAFII-80; TAFII85; TATA box binding protein (Tbp)-associated factor, RNA polymerase II, E; TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD; TATA box binding protein associated factor 6; TATA-box binding protein associated factor 6; TBP-associated factor 6; TBP-associated factor 6 isoform alpha; TFIID subunit p80; transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID 80 kDa subunit; transcription initiation factor TFIID subunit 6; wu:fb83e08; wu:fj30b02; zgc:92160
• Gene Symbols: TAF6
• Host Species: Mouse
• Immunogen: Synthetic peptide coupled to ovalalbumin, from aa 39 to aa 56.
• Quantity: 50 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21343, 6878
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ