Invitrogen™ TAFII p135/p105 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536243

Catalog No. PIPA536243

Description

This antibody detects endogenous protein at a molecular weight of 135 kDa and 105 kDa. Purity is >95% by SDS-PAGE.

TAF II p105, also called TAF4B, is a celltype specific transcriptional co-activator that is a component of the TFIID complex. Expressed primarily in B cells and ovarian granulosa cells, TAF II p105 can interact with OCBA/POU2AF1 to activate B cell-specific octamerdependent transcription. Additionally, TAF II p105 plays an important role in co-activating the transcription factor NFkB and is essential for activation of anti-apoptotic genes such as TNFAIP3. TAF II p135, also known as TAF4, TAF2C, TAF2C1, TAF4A or TAFII130, is a 1,085 amino acid subunit of TFIID that accelerates transcriptional activation triggered by thyroid hormone (TR) or retinoic acid (RA). Localized to the nucleus, TAF II p135 contains one TAFH domain and is thought to bind to proteins that contain glutamine-rich domains, such as the transcription factor CREB.

Specifications

• Antigen: TAFII p135/p105
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TAF4
• Gene Alias: 105kDa; 135kDa; 2610524B04Rik; 4932409F03Rik; AI450312; AW987595; RGD1562997; RNA polymerase II TBP-associated factor subunit C; similar to Transcription initiation factor TFIID 105 kDa subunit (TAFII-105); SPGF13; TAF(II)105; TAF(II)130; TAF(II)135; TAF2C; TAF2C1; Taf2c2; TAF4; TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; Taf4a; TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD; Taf4b; TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; TAFII 130; TAFII 135; TAFII105; TAFII-105; TAFII130; TAFII-130; TAFII135; TAFII-135; TATA box binding protein (TBP)-associated factor 4B; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kd; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD; TATA box binding protein associated factor 4; TATA box binding protein associated factor 4b; TATA-box binding protein associated factor 4; TATA-box binding protein associated factor 4b; TBP-associated factor 4; Transcription initiation factor TFIID 105 kDa subunit; transcription initiation factor TFIID 130 kDa subunit; transcription initiation factor TFIID 135 kD subunit; transcription initiation factor TFIID 135 kDa subunit; Transcription initiation factor TFIID subunit 4; transcription initiation factor TFIID subunit 4B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 228980, 291773, 682097, 6874, 6875, 72504
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: G5E8Z2, O00268, Q92750
• Gene Symbols: TAF4, TAF4B
• Immunogen: Synthetic peptide corresponding to amino acids 951-1000 of human TAF II p135.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG