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Invitrogen™ TAGLN2 Polyclonal Antibody
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Catalog No. PIPA599987
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PIPA599987 100 μL
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Catalog No. PIPA599987 Supplier Invitrogen™ Supplier No. PA599987
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Transgelin 2.

Transgelin (also designated SM22alpha), is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. The human transgelin-2 gene (designated TAGLN2), which is located on chromosome 1q231-q25, encodes a 199 amino acid protein that contains a calponin-like repeat and a calponin-homology (CH) domain. Transgelin-2 may function very similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAGLN2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Tagln2
Gene Accession No. P37802, Q5XFX0, Q9WVA4
Gene Alias 2700094C18Rik; CDABP0035; Epididymis tissue protein Li 7e; HA1756; Kiaa0120; Sm22a; SM22-alpha homolog; Sm22B; SM22beta; SM22-beta; Tagln2; transgelin 2; transgelin-2
Gene Symbols Tagln2
Host Species Rabbit
Immunogen A synthesized peptide derived from human TAGLN2(Accession P37802), corresponding to amino acid residues L129-G179.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21346, 304983, 8407
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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