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Tocris Bioscience™ TAK 242
GREENER_CHOICE

Catalog No. 65875
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Toll-like receptor 4 (TLR4) signaling inhibitor

TAK 242 is a toll-like receptor 4 (TLR4) signaling inhibitor. Binds to intracellular domain of TLR4. Inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production). Reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs). Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Specifications

Chemical Name or Material (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate
CAS 243984-11-4
Quantity 5 mg
Molecular Formula C15H17ClFNO4S
Formula Weight 361.82
Purity 98%
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