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Tocris Bioscience™ TAK 779
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Catalog No. 434010
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Catalog No. Quantity
43-401-0 10 mg
43-405-0 50 mg
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Catalog No. 43-401-0 Supplier Tocris Bioscience™ Supplier No. 4340/10
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Description

Potent and selective CCR5 and CCR2 chemokine receptor antagonist

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Specifications

Chemical Name or Material N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5 H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2 H-pyran-4-aminium chloride
CAS 229005-80-5
Quantity 10 mg
Target Chemokine Receptor Antagonists
Molecular Formula C33H39N2O2.Cl
Purity 0.98
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