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Tocris Bioscience™ Takinib

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Quantity:
5 mg
25 mg
Description
Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.
Specifications
Specifications
Chemical Name or Material | N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide |
CAS | 1111556-37-6 |
Quantity | 5 mg |
Target | Other Kinase Inhibitors |
Molecular Formula | C18H18N4O2 |
Purity | 0.98 |
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