Invitrogen™ TAL-1 Monoclonal Antibody (2TL242), eBioscience™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
14-910-182	Invitrogen™ 14910182	100 μg

Description

Description: The monoclonal antibody 2TL242 recognizes human TAL-1. The TAL-1 protein is encoded by the tal-1 (T-acute leukemia or stem cell leukemia (SCL)) gene and functions as a 42 kDa basic helix loop helix transcription factor involved in mediating cell growth and differentation. Rearrangements of the tal-1 gene are common in human T-cell acute leukemias (T-ALLs) and result in aberrant transcription in leukemic cells. TAL-1 expression in leukemic cells is localized to the nucleus although both nuclear and cytoplasmic expression has been shown in normal cells such as erythroid precursors, megakaryocytes, endothelial cells, and macrophages scattered throughout tissues such as the tonsil, cerebellum, kidney, lung and spleen. TAL-1 is known to regulate both embryonic and adult hematopoiesis and more recently was found to regulate proliferation and differentiation of common myeloid precursors to monocytes and ultimately macrophages within tissue. Applications Reported: This 2TL242 antibody has been reported for use in western blotting, microscopy, immunohistochemical staining, and immunocytochemistry. Applications Tested: This 2TL242 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using either low or high pH antigen retrieval at less than or equal to 20 μg/mL. This 2TL242 antibody has also been tested by western blot of reduced Jurkat cell lysate at less than or equal to 5 μg/mL. It is recommended that the antibody be...

TAL-1 is a basic helix-loop-helix transcription. It regulates differentiation and survival during hemopoiesis. TAL-1 is also implicated in the genesis of hemopoietic malignancies and it may play an important role in hemopoietic differentiation. It serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. TAL-1 is know to bind to the LIM domain containing protein Rhombotin-2.

Specifications

• Antigen: TAL-1
• Concentration: 0.5 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: P17542
• Gene ID (Entrez): 6886
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 2TL242
• Content And Storage: 4°C
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG1 κ
• Target Species: Human
• Gene: TAL1
• Gene Alias: basic helix-loop-helix transcription factor; bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; LOW QUALITY PROTEIN: T-cell acute lymphocytic leukemia protein 1; Scl; scl/tal1; SCL/tal-1; SCL-alpha; SCL-beta; si:ch211-135j1.3; stem cell leukemia protein; stem cell leukemia protein SCL; stem cell protein; stem-cell leukemia hematopoietic transcription factor; T cell acute lymphocytic leukemia 1; TAL bHLH transcription factor 1, erythroid differentiation factor; TAL1; Tal-1; tal-1 product; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1 homolog; T-cell leukemia/lymphoma protein 5; TCL5; transcription factor; zgc:85605; zSCL
• Gene Symbols: TAL1
• Product Type: Antibody