Invitrogen™ Talin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527646

Catalog No. PIPA527646

Description

Recommended positive controls: Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, A549, H1299, HCT116. Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (92%), Chicken (93%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin.

Specifications

• Antigen: Talin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLN1
• Gene Alias: ILWEQ; KIAA1027; talin 1; talin-1; TLN; TLN1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21894, 7094
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P26039, Q9Y490
• Gene Symbols: TLN1
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human Talin-1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG