Tamibarotene, PROMO, Thermo Scientific Chemicals

Description

Applications

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).

Solubility

Soluble to 50 mM in DMSO

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 94497-51-5
• Molecular Formula: C22H25NO3
• Molecular Weight (g/mol): 351.45 g/mol
• MDL Number: MFCD00866188
• InChI Key: MUTNCGKQJGXKEM-UHFFFAOYSA-N
• Synonym: tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
• PubChem CID: 108143
• ChEBI: CHEBI:32181
• IUPAC Name: 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
• SMILES: CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12

• Color: White
• Quantity: 10 mg
• Merck Index: 14,9047
• Solubility Information: Soluble in DMSO
• Physical Form: Solid
• Chemical Name or Material: Tamibarotene

Safety and Handling

RTECSNumber	DH6940000
TSCA	No

RUO - Research Use Only