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Invitrogen™ Tankyrase Polyclonal Antibody
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Catalog No. PIPA568624
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100 μL
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Catalog No. Quantity
PIPA568624 100 μL
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Catalog No. PIPA568624 Supplier Invitrogen™ Supplier No. PA568624
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%.

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tankyrase
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene TNKS
Gene Accession No. 0
Gene Alias 4930554K12Rik; ADP-ribosyltransferase diphtheria toxin-like 5; AI662855; ARTD5; C86528; D130072O21Rik; HGNC:11941; LOW QUALITY PROTEIN: tankyrase-1; mTNKS1; PARP5A; PARP-5a; PARPL; pART5; Poly [ADP-ribose] polymerase 5A; Poly [ADP-ribose] polymerase tankyrase-1; poly [ADP-ribose] polymerase tankyrase-1; tankyrase-1; Protein poly-ADP-ribosyltransferase tankyrase-1; TANK1; tankyrase; tankyrase 1; tankyrase I; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; TIN1; TINF1; TNKS; TNKS1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Gene Symbols TNKS
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human Tankyrase.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 290794
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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