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Invitrogen™ TAOK1 Polyclonal Antibody
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Catalog No. PIPA124577
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25 μg
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Catalog No. Quantity
PIPA124577 25 μg
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Catalog No. PIPA124577 Supplier Invitrogen™ Supplier No. PA124577
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Description

Rabbit Polyclonal Antibody

PA1-24577 detects Serine/threonine kinase TAO kinase 1 in Human samples.

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay. TAOK1 is involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAOK1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene TAOK1
Gene Accession No. O88664, Q5F2E8, Q7L7X3
Gene Alias 2810468K05Rik; AU020252; D130018F14Rik; FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; hTAOK1; KFC-B; Kiaa1361; Kinase from chicken homolog B; MAP3K16; MARK Kinase; Markk; microtubule affinity regulating kinase kinase; mKIAA1361; prostate-derived STE20-like kinase 2; prostate-derived sterile 20-like kinase 2; PSK2; PSK-2; serine/threonine protein kinase TAO1; serine/threonine protein kinase TAO1 homolog; serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; tao; TAO kinase 1; TAO1; TAOK1; Thousand and one amino acid protein 1; thousand and one amino acid protein kinase 1
Gene Symbols TAOK1
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from internal region of human TAOK1.
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100059705, 100342573, 100622172, 100758772, 216965, 286993, 480632, 536532, 57551
Target Species Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Horse, Frog, Frog
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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