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Invitrogen™ TAP2 Polyclonal Antibody
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Catalog No. PIPA551558
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PIPA551558 100 μL
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Catalog No. PIPA551558 Supplier Invitrogen™ Supplier No. PA551558
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GSGKSTVAAL LQNLYQPTGG QVLLDEKPIS QYEHCYLHSQ VVSVGQEPVL FSGSVRNNIA YGLQSCEDDK VMAAAQAAHA DDFIQEMEHG IYTDVGEKGS QLAAGQKQRL AIARALVRDP RVLILDEATS ALDVQCEQA Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAP2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TAP2
Gene Accession No. Q03519
Gene Alias ABC transporter, MHC 2; ABC18; ABCB3; AI462429; Antigen peptide transporter 2; APT2; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; Cim; D6S217E; Ham2; Ham-2; Histocompatibility antigen modifier 2; jas; MTP2; Peptide supply factor 2; peptide transporter involved in antigen processing 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; PSF-2; Really interesting new gene 11 protein; RING11; TAP2; Tap-2; Transporter 2 ABC (ATP binding cassette); transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette); transporter 2, ATP binding cassette subfamily B member; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Y1
Gene Symbols TAP2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TAP2. Recombinant protein control fragment (Product #RP-95379).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6891
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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