Invitrogen™ TAPP1 Polyclonal Antibody

Catalog No.	Quantity
PIPA566719	100 μL

Catalog No. PIPA566719 Supplier Invitrogen™ Supplier No. PA566719

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ITVPKQSDSQP NSDNLSRHGE CGKKQVSYRT DIVGGVPIIT PTQKEEVNEC GESIDRNNLK RSQSHLPYFT PKPPQ Highest antigen sequence identity to the following orthologs - mouse 91%, rat 92%.

Phosphatidylinositol-4,5-bisphosphate 3-phosphatase adapter protein 1 (TAPP1) is a gene located on chromosome 1q25.2, encoding a protein involved in intracellular signaling pathways that regulate cellular processes such as proliferation, survival, and migration. TAPP1 is characterized by containing pleckstrin homology (PH) domains, which allow it to bind specifically to phosphoinositide lipids, particularly phosphatidylinositol (3,4) bisphosphate. This interaction is crucial for the localization of TAPP1 to cell membranes where it can act as an adaptor protein, modulating the activity of downstream signaling molecules and pathways. TAPP1 is expressed in various tissues and plays a role in immune cell function, influencing processes like cell motility and cytoskeletal dynamics. Research into TAPP1 focuses on its role in immune regulation and signaling, with implications for understanding its function in disease contexts such as cancer and autoimmune disorders where phosphoinositide signaling is disrupted.

Specifications

• Antigen: TAPP1
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PLEKHA1
• Gene Accession No.: Q9HB21
• Gene Alias: AA960558; C920009D07Rik; PH domain-containing family A member 1; pleckstrin homology domain containing A1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; pleckstrin homology domain-containing protein family A member 1; PLEKHA1; RGD1564153; tandem PH domain containing protein-1; tandem PH domain-containing protein 1; TAPP1; TAPP-1
• Gene Symbols: PLEKHA1
• Host Species: Rabbit
• Immunogen: Recombinant Human TAPP1. Recombinant protein control fragment (Product #RP-107371).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 59338
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG