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  5. Tocris Bioscience™ Tariquidar dihydrochloride

Tocris Bioscience™ Tariquidar dihydrochloride
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Catalog No. 575750
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57-575-0 50 mg
57-571-0 10 mg
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Catalog No. 57-575-0 Supplier Tocris Bioscience™ Supplier No. 5757/50
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Description

Potent P-glycoprotein (P-gp) inhibitor

Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro.

Specifications

Chemical Name or Material N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride
CAS 1992047-62-7
Quantity 50 mg
Target Multidrug Transporter Inhibitors
Molecular Formula C38H38N4O6.2HCl
Formula Weight 719.66
Purity >98%
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