Invitrogen™ TAS2R38 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590212

Catalog No. PIPA590212

Description

Immunogen sequence: CSCICTVLCV WCFFSRPHFT VTTVLFMNNN TRLNWQIKDL NLFYSFLFCY LWSVPPFLLF LVSSGMLTVS LGRHMRTMKV YTRNSRDPSL EAHIKALKSL V; Positive Samples: rat thymus; Cellular Location: Membrane, Multi-pass membrane protein.

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting); also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

Specifications

• Antigen: TAS2R38
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tas2r138
• Gene Alias: mt2r31; PTC; PTC bitter taste receptor; RGD:1560649}; T2R138; T2R26; T2r31; T2r38; T2r38 {ECO:0000312; T2R61; Tas2r138; Tas2r26; TAS2R38; taste 2 receptor member 38; taste receptor type 2 member 26; Taste receptor type 2 member 38; taste receptor type 2 member 61; taste receptor, type 2, member 138; taste receptor, type 2, member 38
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 500091
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.87 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q4VHE7
• Gene Symbols: Tas2r138
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_7897874).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG