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Tocris Bioscience™ TASP 0277308
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Catalog No. 64985
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5 mg
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64-985 5 mg
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Catalog No. 64-985 Supplier Tocris Bioscience™ Supplier No. 6498/5
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Description

Potent and selective S1P1 receptor antagonist; inhibits angiogenesis

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesis in vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.

Specifications

Chemical Name or Material 3,4-Dichloro-N-[(1 R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4 H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
CAS 945725-50-8
Quantity 5 mg
Target Sphingosine-1-phosphate Receptor Antagonists
Molecular Formula C23H28Cl2N6O3S
Purity 0.98
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