Tocris Bioscience™ TASP 0433864

Description

Selective mGlu2 receptor positive allosteric modulator

TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.

Specifications

• Chemical Name or Material: (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide
• CAS: 1431980-60-7
• Synonym: mGlu2 receptor positive allosteric modulator
• Quantity: 50 mg
• Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
• Molecular Formula: C₁₈H₂₃N₃O₃
• Formula Weight: 329.39
• Physical Form: Solid
• Color: White
• Product Type: Bioactive Small Molecule
• Purity: >98%

For Research Use Only.