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Tocris Bioscience™ TASP 0433864

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Quantity:
10 mg
50 mg
Description
TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
Specifications
Specifications
Chemical Name or Material | (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide |
CAS | 1431980-60-7 |
Synonym | mGlu2 receptor positive allosteric modulator |
Quantity | 50 mg |
Solubility | Soluble to 100mM in DMSO and to 20mM in ethanol |
Molecular Formula | C18H23N3O3 |
Formula Weight | 329.39 |
Physical Form | Solid |
Color | White |
Product Type | Bioactive Small Molecule |
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For Research Use Only.
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