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Invitrogen™ TATDN3 Polyclonal Antibody
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Catalog No. PIPA556922
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100 μL
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PIPA556922 100 μL
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Catalog No. PIPA556922 Supplier Invitrogen™ Supplier No. PA556922
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AGVGLVDCHC HLSAPDFDRD LDDVLEKAKK ANVVALVAVA EHSGEFEKIM QLSERYNGFV LPCL Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 28%.

The TATDN3 gene encodes the protein TatD DNase domain containing 3, which belongs to a family of nucleases with a range of enzymatic activities. TATDN3 is known to exhibit apurinic/apyrimidinic (AP) endonuclease activity, which is crucial for DNA repair mechanisms, particularly in the recognition and removal of damaged bases. Structurally, the TatD family proteins, including TATDN3, possess a conserved nuclease domain that enables their function in DNA metabolism. Studies demonstrate that TATDN3 can also display 3'-5' exonuclease activity, further contributing to genome stability by processing DNA ends. Phylogenetically, TATDN3 represents a distinct clade with unique active site motifs, differentiating it from other paralogs such as TATDN1. Given its involvement in critical cellular processes, TATDN3 is an important factor in maintaining genomic integrity and preventing mutations that may lead to diseases such as cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TATDN3
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TATDN3
Gene Accession No. Q17R31
Gene Alias 1500010M24Rik; Putative deoxyribonuclease TATDN3; TatD DNase domain containing 3; TATDN3
Gene Symbols TATDN3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TATDN3. Recombinant protein control fragment (Product #RP-94563).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 128387
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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