Invitrogen™ TATDN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556922

Catalog No. PIPA556922

Description

Immunogen sequence: AGVGLVDCHC HLSAPDFDRD LDDVLEKAKK ANVVALVAVA EHSGEFEKIM QLSERYNGFV LPCL Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 28%.

The TATDN3 gene encodes the protein TatD DNase domain containing 3, which belongs to a family of nucleases with a range of enzymatic activities. TATDN3 is known to exhibit apurinic/apyrimidinic (AP) endonuclease activity, which is crucial for DNA repair mechanisms, particularly in the recognition and removal of damaged bases. Structurally, the TatD family proteins, including TATDN3, possess a conserved nuclease domain that enables their function in DNA metabolism. Studies demonstrate that TATDN3 can also display 3'-5' exonuclease activity, further contributing to genome stability by processing DNA ends. Phylogenetically, TATDN3 represents a distinct clade with unique active site motifs, differentiating it from other paralogs such as TATDN1. Given its involvement in critical cellular processes, TATDN3 is an important factor in maintaining genomic integrity and preventing mutations that may lead to diseases such as cancer.

Specifications

• Antigen: TATDN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TATDN3
• Gene Alias: 1500010M24Rik; Putative deoxyribonuclease TATDN3; TatD DNase domain containing 3; TATDN3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 128387
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q17R31
• Gene Symbols: TATDN3
• Immunogen: Recombinant protein corresponding to Human TATDN3. Recombinant protein control fragment (Product #RP-94563).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG