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TAU Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1E9A8, Proteintech
SDP

Mouse Monoclonal Antibody

$518.60

Specifications

Antigen TAU
Clone 1E9A8
Concentration 1 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-173-6922
SDP
Encompass_Preferred
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Proteintech Group Inc
664991IG150UL
150 μL
Each of 1 for $518.60
Only null left
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Description

Description

Tau is a neuronal microtubule-associated protein found predomitly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer′s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Specifications

Specifications

TAU
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
DDPAC, FTDP 17, MAPT, MAPTL, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, PPND, TAU
Mapt
IgG2c
Protein A
Antibody
1E9A8
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Mouse
Human, Mouse, Pig, Rat
P10636, P10637, P19332
100738351, 17762, 29477, 4137
TAU Fusion Protein Ag21926
Primary
-20°C
MAPT
Videos
SDS
Documents

Documents

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