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TBC1D1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501569858
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50-156-9858 10 μL
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Catalog No. 50-156-9858 Supplier Bethyl Laboratories, Inc Supplier No. A305226AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.

Specifications

Antigen TBC1D1
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene TBC1D1
Gene Accession No. Q86TI0
Gene Alias TBC, TBC1; TBC1 domain family member 1
Gene Symbols TBC1D1
Host Species Rabbit
Immunogen Between 1118 and 1168
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23216
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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