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Invitrogen™ TBC1D23 Polyclonal Antibody
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Catalog No. PIPA558274
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100 μL
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PIPA558274 100 μL
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Catalog No. PIPA558274 Supplier Invitrogen™ Supplier No. PA558274
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HLSTAFHLDS DLMLQNPSEF AQSVKSLLEA QKQSIESGSI AGGEHLCFMG SGREEEDMYM NMVLAHFLQK NKEYVSIASG GFMALQQHLA DINVDGPENG Y Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen TBC1D23
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TBC1D23
Gene Accession No. Q9NUY8
Gene Alias 4930451A13Rik; AU015720; AU043671; AU043778; D030022P07Rik; HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; hypothetical protein LOC393459; NS4ATP1; RGD1307925; TBC1 domain family member 23; TBC1 domain family, member 23; TBC1D23; W51689; zgc:63756
Gene Symbols TBC1D23
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TBC1D23. Recombinant protein control fragment (Product #RP-96258).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55773
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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