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Tocris Bioscience™ TBIA

Catalog No. 778810
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77-881-0 10 mg
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Catalog No. 77-881-0 Supplier Tocris Bioscience™ Supplier No. 7788/10
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Description

Bivalent SHAPE cross-linking reagent

TBIA (trans-bis-isatoic anhydride) is a bifunctional SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) chemical cross-linking reagent. TBIA has two electrophilic isatoic anhydride moieties, both of which can react with the 2'-OH group in nucleotides adjacent to and distant from the primary RNA sequence. TBIA is used in SHAPE-JuMP (-juxtaposed merged pairs) a technique for exploring RNA tertiary structure proximity on large RNAs, and higher-order RNA-RNA interactions at nanometer resolution.

Specifications

Chemical Name or Material 1,6-Dihydrobenzo[1,2-d:4,5-d']bis([1,3]oxazine)-2,4,7,9-tetraone
Quantity 10 mg
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C10H4N2O6
Purity 95%
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