Invitrogen™ TBLR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530861

Catalog No. PIPA530861

Description

Recommended positive controls: HeLa, HepG2, HCT116. Predicted reactivity: Mouse (96%), Rat (97%), Xenopus laevis (91%), Chicken (98%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.

Specifications

• Antigen: TBLR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TBL1XR1
• Gene Alias: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; Ira1; MRD41; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; RGD1560053; TBL1-related protein 1; TBL1XR1; TBLR1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta)-like 1X-linked receptor 1; transducin beta-like 1X-related protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79718
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.93 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9BZK7
• Gene Symbols: TBL1XR1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human TBLR1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov