Invitrogen™ TBLR1 Polyclonal Antibody

Catalog No.	Quantity
PIPA582671	100 μL

Catalog No. PIPA582671 Supplier Invitrogen™ Supplier No. PA582671

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RPIESLSLID AVMPDVVQTR QQAYRDKLAQ QQAAAAAAAA AAASQQGSAK NGENTANGEE NGAHTIANNH TDMMEVDGDV EIPPNKAVVL RGHE Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 96%.

Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.

Specifications

• Antigen: TBLR1
• Applications: ChIP Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: TBL1XR1
• Gene Accession No.: Q9BZK7
• Gene Alias: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; Ira1; MRD41; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; RGD1560053; TBL1-related protein 1; TBL1XR1; TBLR1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta)-like 1X-linked receptor 1; transducin beta-like 1X-related protein 1
• Gene Symbols: TBL1XR1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human TBL1XR1. Recombinant protein control fragment (Product #RP-91034).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79718
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG