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Invitrogen™ TBLR1 Polyclonal Antibody
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Catalog No. PIPA589235
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100 μL
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PIPA589235 100 μL
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Catalog No. PIPA589235 Supplier Invitrogen™ Supplier No. PA589235
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QQGSAKNGEN TANGEENGAH TIANNHTDMM EVDGDVEIPP NKAVVLRGHE S Positive Samples: Jurkat, HepG2, NCI-H460, THP-1, Mouse brain, Mouse spleen, Mouse thymus; Cellular Location: Nucleus.

Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TBLR1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.15 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene TBL1XR1
Gene Accession No. Q8BHJ5, Q9BZK7
Gene Alias 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; Ira1; MRD41; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; RGD1560053; TBL1-related protein 1; TBL1XR1; TBLR1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta)-like 1X-linked receptor 1; transducin beta-like 1X-related protein 1
Gene Symbols TBL1XR1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 120-170 of human TBL1XR1 (NP_0789412).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79718, 81004
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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