MilliporeSigma™ TBX1, Mouse, Unlabeled, Clone: 7E12.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN720

Catalog No. MABN720MI

Description

T-box transcription factor TBX1 (UniProt O43435; also known as T-box protein 1, Testis-specific T-box protein) is encoded by the TBX1 (also known as CTHM, DGS, TBX1C, VCFS) gene (Gene ID 6899) in human. TBX1 blongs to the T-box family of transcription factors that play important roles in the formation of tissues and organs during embryonic development. TBX1 is required for the second heart field (SHF) development for outflow tract development by regulating proliferation and differentiation of SHF cells. TBX1 is also shown to negatively regulate thymic epithelial cell (TEC) growth and differentiation in mice, extinction of Tbx1 gene expression in the third pharyngeal pouch (3rd pp) endoderm is a prerequisite for thymus organogenesis. Human TBX mutations cause DiGeorge syndrome, characterized by parathyroid hypoplasia, thymic hypoplasia, defects in the outflow tract of the heart, and craniofacial anomalies.

Specifications

• Antigen: TBX1
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Mouse monoclonal IgG2aκ hybridoma culture supernatant without preservatives.
• Gene Accession No.: O43435
• Immunogen: GST-tagged recombinant human TBX1 C-terminal fragment.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_542377
• Target Species: Human
• Form: Culture Supernatant

• Applications: Western Blot
• Clone: 7E12.1
• Conjugate: Unconjugated
• Gene: TBX1, CTHM, DGS, TBX1C, VCFS
• Host Species: Mouse
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 7E12.1 was raised against a recombinant fragment derived from TBX1 spliced isoform A (Uniprot O43435-1), cross-reactivity toward spliced isoform B and isoform C (TBX1C) is possible, but has not been determined.
• Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
• Isotype: IgG2a κ

For Research Use Only. Not for use in diagnostic procedures.