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Invitrogen™ TBX3 Polyclonal Antibody

Catalog No. PIPA5121561
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200 μL
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PIPA5121561 20 μL
PIPA5119454 200 μL
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Catalog No. PIPA5121561 Supplier Invitrogen™ Supplier No. PA5121561
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Description

Rabbit Polyclonal Antibody

TBX3 Polyclonal Antibody for Western Blot, IHC

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TBX3
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Tbx3
Gene Accession No. O15119
Gene Alias bladder cancer related protein XHL; D5Ertd189e; T-box 3; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; UMS; XHL
Gene Symbols Tbx3
Host Species Rabbit
Immunogen Recombinant protein T-Box Protein 3. The antigen corresponds to amino acid range 107-220 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6926
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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