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Invitrogen™ TBX3 Recombinant Superclonal™ Antibody (22HCLC)

Rabbit Recombinant Superclonal Antibody

Supplier:  Invitrogen™ 711087

Catalog No. PI711087


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Description

Description

TBX3 Recombinant Polyclonal Antibody for ICC/IF, ChIP

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TBX3
Recombinant Superclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O15119
Tbx3
Protein corresponding to Human TBX3 (aa 305-500).
100 μg
Primary
Human
Antibody
IgG
ChIP Assay, Immunocytochemistry
22HCLC
Unconjugated
Tbx3
bladder cancer related protein XHL; D5Ertd189e; T-box 3; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; UMS; XHL
Rabbit
Protein A
RUO
6926
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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