Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ TBX3 Recombinant Superclonal™ Antibody (22HCLC)
Rabbit Recombinant Superclonal Antibody
Supplier: Invitrogen™ 711087
Description
TBX3 Recombinant Polyclonal Antibody for ICC/IF, ChIP
T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.
Specifications
TBX3 | |
Recombinant Superclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
O15119 | |
Tbx3 | |
Protein corresponding to Human TBX3 (aa 305-500). | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
ChIP Assay, Immunocytochemistry | |
22HCLC | |
Unconjugated | |
Tbx3 | |
bladder cancer related protein XHL; D5Ertd189e; T-box 3; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; UMS; XHL | |
Rabbit | |
Protein A | |
RUO | |
6926 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction