Invitrogen™ TBX3 Recombinant Rabbit Monoclonal Antibody (JE33-38)

Catalog No.	Quantity
FEMA550714	100 μL

Catalog No. FEMA550714 Supplier Invitrogen™ Supplier No. MA550714

Description

Rabbit Recombinant Monoclonal Antibody

Positive control: JAR cell lysates, HepG2. Predicted band size: 79 kDa Subcellular Location: Nucleus.

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.

Specifications

• Antigen: TBX3
• Applications: Flow Cytometry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: JE33-38
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: Tbx3
• Gene Accession No.: O15119
• Gene Alias: bladder cancer related protein XHL; D5Ertd189e; T-box 3; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; UMS; XHL
• Gene Symbols: Tbx3
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human Tbx3 aa 694-743/743.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6926
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG